Research

Research Activities and Funding:

Summary: I have been the principal or co-principal investigator in over 60 research grants and contracts, exceeding US $21 million (my own portion at USC only).  The total funding level of these grants exceeds US $45 million.  These grants are described below:

Synopsis of our work
USC signature aerosol technologies

Current: 

  1. Neurotoxicity of Airborne Particles: Role of Chronic Cerebral Hypoperfusion

Funding Source: National Institute of Health – NIEHS/ONES

Role: Co-Principal Investigator  (PI: Dr. William Mack, USC Medical School)

Project period: 03 /01/2015 – 3/01/2020

Total Amount of Award: $ 3,875,000 (C. Sioutas share at USC; $515,500)

 

  1. Fossil-fuel urban particles and neurodegeneration in Alzheimer transgenic mice

Funding Source: National Institute of Health

Role: Co-Principal Investigator  (PI: Caleb Finch, USC Dept of Gerontology)

Project period: 12 /01/2015 – 12/01/2018

Total Amount of Award: $ 535,000 (C. Sioutas share at USC; $105,500)

 

  1. Inflammation in brain aging: modulation by apoE alleles, gender, and air pollution

Funding Source: National Institute of Health

Role: Co-Principal Investigator  (PI: Caleb Finch, USC Dept Gerontology)

Project period: 12 /01/2015 – 12/01/2020

Total Amount of Award: $ 3,035,000 (C. Sioutas share at USC; $505,500)

 

  1. Airborne pollutants as triggers of Parkinson’s disease via the olfactory system.

Funding Source:  Department of Defense

Role: Co-Principal Investigator  (PI: Caleb Finch, USC Dept Gerontology)

Project period: 10 /01/2017 – 12/01/2021

Total Amount of Award: $ 2,500,000 (C. Sioutas share at USC; $436,500)

 

  1. Genetic and Epigenetic Programming of Allergic Airway Inflammation

Funding Source:  National Institute of Health NIH

Role: Co- Principal Investigator  (PI: Talal Chatila, Harvard Medical School)

Project period: 12/01/2017 – 12/01/2022

Total Amount of Award: $ 3,009,000 ((C. Sioutas share at USC; $576,718)

 

  1. Urban Air Pollution and Alzheimer’s Disease: Risk, Heterogeneity, and Mechanisms- PO1 Award

Funding Source:  National Institute of Health/National Institute of Aging

Role: Co-Principal Investigator and Core Director  (PI:Caleb Finch, USC Dept Gerontology)

Project period: 10/01/2018 -10/31/2023

Total Amount of Award: $ 12,345,000.00 (C. Sioutas share at USC: $592,061)

 

  1. Role of Intestinal Microbiota in Dyslipidemia and Atherosclerosis Induced by Ambient Ultrafine Particles

Funding Source: National Institute of Health/National Institute of Environmental Health Sciences

Role: Co-Principal Investigator

Project period: 11/01/2018 – 10/31/2023 (PI- Jesus Araujo, UCLA School of Medicine)

Total Amount of Award: $ 2,500,000 (C. Sioutas share at USC: $475,000)

 

 

 

Previous Funding:

 

  1. Development of a Mobile Exposure Facility to Conduct Inhalation Exposures to Ambient Particles

 

Funding Source: Air Resources Board, State of California

Role:  Co-Principal Investigator (PI: John Froines. University of California, Los Angeles, School of Public Health)

Project period: 09/01/99-12/30/05

Total Amount of Award: $2,500,000 (USC School of Engineering share: $746,950)

 

  1. SOUTHERN CALIFORNIA AIRBORNE PARTICULATE MATTER CENTER (SCAPMC)

 

Funding Source: U.S. Environmental Protection Agency

Role:  Co-Principal Investigator and Director of Exposure Core (Center Director: John Froines. University of California, Los Angeles, School of Public Health)

Project period: 09/01/99-09/30/05 (6 yr renewal pending)

Total Amount of Award: $ 10,719,360 (USC School of Engineering: $1,535,231)

 

  1. SOUTHERN CALIFORNIA SUPERSITE (SCS)

 

Funding Source: U.S. Environmental Protection Agency

Role:  Co-Principal Investigator (Principal Investigator: John Froines. University of California, Los Angeles, School of Public Health)

Project period: 03/01/00-05/31/05

Total Amount of Award: $ 3,699,573 (USC School of Engineering Share: $ 572,140)

 

  1. Development and Evaluation of a Novel Sampling Method to Determine the Phase Partitioning of Semi-Volatile Organic Compounds.

 

Funding source: Harvard University (subcontract to USC; Primary Agency; U.S. EPA)

Role:    Principal Investigator

Project period: 10/01/96-1/31/02

Total Amount of Award:  $150,000

 

5.   Experimental Characterization of Aerosol Separators for Capture Effectiveness

 

Funding Source: Johns Hopkins University; Applied Physics Laboratory

Role: Principal Investigator

Project period: 09/01/98-08/31/00

Total Amount of Award: $78,073      

 

  1. Controlled Laboratory Evaluation of Acute Cardiopulmonary Responses to Concentrated Particulates

 

Funding Source: Health Effects Institute

Role: Co-Principal Investigator (PI: Gong, H.Jr, University of Southern California, School of Medicine)

Project period: 08/01/98-04/30/01

Total Amount of Award:  $ 614,385  

 

  1. Collection, Chemical and Toxicological Characterization of Ambient Coarse, Fine and Ultrafine Particulate Matter

 

Funding Source: Ministry of Housing, Planning and the Environment of the Netherlands

Role: Principal Investigator

Project period: 11/01/98-12/31/99

Total Amount of Award:  $ 89,530    

 

  1. Development and Evaluation of Three Ambient Particle Concentrators for Animal and Human Inhalation Studies

 

Funding source: Harvard University (subcontract to USC; Primary Agency; Health Effects Institute)

Role:    Principal Investigator

Project period: 07/01/98-06/30/99

Total Amount of Award:  $60,480.00

  1. Health Effects of Concentrated Ambient Particles from the Central Valley of California

 

Funding Source: U.S. Environmental Protection Agency

Role:  Co-Principal Investigator (Principal Investigator: Kent Pinkerton, University of California, Davis, Institute of Toxicology and Environmental Health)

Project period: 06/01/00-5/31/03

Total Amount of Award: $ 593,071 (USC School of Engineering Share: $198,062)

 

  1. Acute Cardiopulmonary Responses to Oxidant Gases and Ambient Particulate Pollution in Los Angeles residents

 

Funding Source: U.S. Environmental Protection Agency

Role:  Co-Principal Investigator (Principal Investigator: Henry Gong, Jr., University of Southern California, School of Medicine)

Project period: 06/01/00-5/31/03

Total Amount of Award: $ 623,038

 

  1. Development and Evaluation of a Personal Particle Monitor for Size-Dependent Measurement of Mass and Chemical Composition of Individual Exposures to Particulate Matter

 

Funding Source: Mickey Leland National Air Toxics Research Center

Role: Principal Investigator

Project period: 11/01/00-10/31/02

Total Amount of Award: $297,973.

 

  1. Development and Evaluation of a Coarse Particle Concentrator for Animal Toxicology Studies to Coarse Particulate Matter

 

Funding Source: Ministry of Housing, Spatial Planning and the Environment, Netherlands

Role: Principal Investigator

Project period: 04/01/00-6/31/01

Total Amount of Award: $107,485

 

  1. Development of a Mobile Inhalation Toxicology Facility to Support Air Pollution Studies in Taiwan”

 

Funding Source: Environmental Protection Agency of Taiwan

Role: Principal Investigator

Project period: 04/01/00-3/31/01

Total Amount of Award: $ 50,000

 

  1. Relationship between ambient PM and heart rate variability and cardiac arrhythmia in elderly populations in the Los Angeles Basin

 

Funding Source: California Environmental Protection Agency

Role: Principal Investigator

Project period: 04/01/00-3/31/01

Total Amount of Award: $ 93,476

 

  1. Deployment and Operation of SMPS and Low Temperature TEOM in locations of the USC Children’s Health Study (CHS) and the Los Angeles Supersite

 

Funding Source: California Air Resources Board and Air Quality Management District

Role: Principal Investigator

Project period: 12/01/01-11/30/04

Total Amount of Award: $ 247,115

 

  1. Effects of Airborne Particles on Allergic Airway Disease

 

Funding Source: U.S. Environmental Protection Agency

Role: Co-Principal Investigator (PI: Dr. Jack Harkema, Michigan State University)

Project period: 12/01/01-11/30/04

Total Amount of Award: $ 854,702

 

  1. Development of an Ultrafine Particle Concentrator

 

Funding Source: National Institute of Public Health and the Environment of the Netherlands (RIVM)

Role: Principal Investigator

Project period: /1//1/02 – 12/31/02

Total Amount of Award: $ 88,274

 

  1. Ultrafine Particle Concentrator Facility for Chronic Exposure Studies

 

Funding Source: New York University (NYU)

Role: Principal Investigator

Project period: 03/01/02-06/01/02

Total Amount of Award: $ 48,174

 

  1. Development of a Technology for High Volume Collection of Ultrafine, Accumulation and Coarse PM for In Vitro Toxicology Studies

 

Funding Source: University of Montana

Role: Principal Investigator

Project period: 03/01/03-06/01/03

Total Amount of Award: $ 138,174

 

  1. Development Of A Coarse Particle Chemical Speciation Sampler Using a Virtual Impactor Particle Concentrator

 

Funding Source: U.S. Environmental Protection Agency

Role: Principal Investigator

Project period: 03/01/03-06/01/03 (Cooperative Research and Development Agreement, CREDA)

Total Amount of Award: $ 163,234

 

  1. A Simple Low-cost Beta Attenuation Monitor (BAM) for Continuous Measurement of PM2.5 or Ultrafine Particle Concentrations

 

Funding source:  California Air Resources Board, ICAT Grant 2003

Role:    Co- Principal Investigator (with Philip M. Fine, USC)

Project period:  07/01/03 – 06/30/05

Total Amount of Award: $ 287,660

 

  1. 22. A Pilot Study to Characterize Five Particles in the Environment of an Auto- Manufacturing Facility

 

Funding source:  UAW/Chrysler National Training Center

Role:    Principal Investigator

Project period:  07/01/96 – 06/30/97

Total Amount of Award: $ 24,197

 

  1. Development of an Ambient Fine Particle Concentrator for Human Inhalation Exposure Studies. 

 

Funding source: National Institute of Public Health and Environmental Protection of the Netherlands                            (RIVM)

Role:    Principal Investigator

Project period: 12/01/96-11/30/97

Total Amount of Award: $ 127,115

 

  1. Acute Cardiopulmonary Responses to Concentrated Particulates (Supplement)

Funding Source: Health Effects Institute

Role: Principal Investigator

Project period: 08/01/98-3/31/00

Total Amount of Award:  $ 31,829    

 

  1. An Automated Aerosol Concentration System for the Collection of Suspended Particulate Matter in Aqueous Solutions Suitable for Toxicological Assays

 

Funding Source: South Coast Air Quality Management District

Role: Principal Investigator

Project period: 09/01/04-8/31/06

Total Amount of Award:  $ 214,195  

 

  1. Homeland Security Center for Risk Based Economic Analysis of Terrorist Events

 

Funding Source: Department of Homeland Security

Role: Co- Investigator (Principal Investigator; Randolph Hall, USC School of Engineering)

Project period: 04/01/04-03/31/07

Total Amount of Award:  $12,000,000 (C. Sioutas share: $ 424,000)

 

  1. Development and Evaluation of Aerosol Instrumentation

Funding Source: TSI Incorporated

Role: Principal Investigator

Project period: 02/1/2005 to 10/31/2005

Total Amount of Award:  $ 110,000

 

  1. Center for Agricultural Disease and Injury Research, Prevention and Education

 

Funding Source: National Institute of Occupational Safety and Health (NIOSH)

Role:  Co-Principal Investigator (Principal Investigator: Kent Pinkerton, University of California, Davis, Institute of Toxicology and Environmental Health)

Project period: 09/30/01-08/31/07

Total Amount of Award: $ 593,071 (USC School of Engineering Share: $108,062

 

  • Pediatric Asthma, Particulate Air Pollution and Nitrogen Dioxide

 

Funding Source: National Institutes of Health.

Role: Co- Principal Investigator (PI; Dr. Ralph J. Delfino, UC Irvine)

Project period; 04/01/2002 to 05/31/2008.

Total Amount of Award: $ 1,899,203 (USC School of Engineering share; $220,506)

 

30        Ultrafine PM and Cardio Respiratory Health

 

Funding Source: National Institute of Environmental Health Sciences (NIEHS-NIH)

Role: Co-Principal Investigator (with Ralph Delfino, UC Irvine)

Project period: 12/01/03-11/30/08

Total Amount of Award: $ 2,817,789 (USC School of Engineering Share: $715,000)

 

  • Determination of Reactive Oxygen Species Activity in PM and Enhanced Exposure Assessment for the NIH, NIEHS Study Entitled: Ultrafine Particulate Matter and Cardiorespiratory Health

 

Funding Source: South Coast Air Quality Management District

Role: Co- Principal Investigator (with Ralph Delfino, UC Irvine

Project period: 09/1/2004 to 10/31/2008

Total Amount of Award:  $750,000 (USC SOE share: $ 314,000)

 

  • Atherogenic Effects of Ambient PM in Susceptible Animals

 

Funding Source: National Institute of Environmental Health Sciences (NIEHS-NIH)

Role: Co- Principal Investigator (with Andre Nel, UCLA School of Medicine)

Project period: 09/1/2004 to 12/31/2008

Total Amount of Award:  $1,530,000 (USC SOE share: $ 391,330)

 

  • Toxicological assessment of particulate emissions from the exhaust of old and new model heavy- and light-duty vehicles

Funding Source: METRANS Transportation Center- US DOT.

Role:  Co-Principal Investigator (with Dr. Katharine Moore, USC)

Project period: 10/01/2008-12/31/2009

Total Amount of Award: $ 100,000

 

  1. Cardiovascular Effects of Ambient PM in Susceptible Animals

 

Funding Source: National Institute of Environmental Health Sciences (NIEHS-NIH)

Role: Co- Investigator (PI; Michael T. Kleinman, UC Irvine School of Medicine)

Project period: 09/1/2004 to 08/31/2008

Total Amount of Award:  $ 750,000 (USC SOE share: $ 150,650)

 

  1. Design and evaluation of two high-flow rate, very low pressure drop impactors for collection of coarse, fine and ultrafine particles

Funding Source: US EPA

Role:  Principal Investigator

Project period: 04/01/2008-12/31/2009

Total Amount of Award: $ 94,244

 

  1. MEGacity Aerosols Characterization and Toxicity ( MEGATOX)

Funding Source: Ecole des Mines de Douai, Paris, France.

Role:  Principal Investigator

Project period: 04/01/2009-12/31/2009

Total Amount of Award: $ 126,750

 

  1. Fine Scale Particle Number Concentrations Within Communities and in the Vicinity of Sound Walls

 

Funding Source: California Air Resources Board

Role:  Principal Investigator

Project period: 12/01/2007-06/06/2011

Total Amount of Award: $ 467,000

 

  1. Physicochemical and toxicological assessment of the semi-volatile and non-volatile fractions of PM from heavy- and light-duty vehicles operating with and without emissions control technologies

 

Funding Source: California Air Resources Board

Role:  Principal Investigator

Project period: 01/01/2007-12/31/2011

Total Amount of Award: $ 679,000

 

  1. Measurement and Toxicological Assessment of Population Exposures to Airborne Particulate Matter (PM) in Subways and Light Rail Trains

 

Funding Source: METRANS Transportation Center- US DOT.

Role:  Co-Principal Investigator (with Dr. Katharine Moore, USC)

Project period: 10/01/2009-12/31/2011

Total Amount of Award: $ 100,000

 

  1. SOUTHERN CALIFORNIA AIRBORNE PARTICULATE MATTER CENTER (SCAPMC) Renewal

Funding Source: U.S. Environmental Protection Agency

Role:  Co-Director (Center Director: John Froines. University of California, Los Angeles, School of Public Health)

Project period: 01/01/2006-12/31/2012 (6 yr renewal)

Total Amount of Award: $ 7,999,360 (USC School of Engineering: $2,135,231)

 

  1. Asthma Allergic Disease Research Center (AADCRC)

Funding Source: National Institute of Health

Role:  Exposure Core Director (Center Director; Andre Nel, UCLA School of Medicine)

Project period: 11/01/2006-10/31/2012

Total Amount of Award: $ 678,000 (USC School of Engineering share); total amount awarded: $6,136,890.

 

 

  1. Sources, Composition, Variability and Toxicological Characteristics of Coarse (PM10-2.5) Particles in Southern California

Funding Source: US EPA

Role:  Principal Investigator

Project period: 01/01/2008-12/31/2012

Total Amount of Award: $ 1,120,641

 

  1. Center for Genomic and Phenomic Studies in Autism (U24)

Funding Source: NIH

Role:  Co-Principal Investigator (Principal Investigator: Dr. Clara Lajonchere, USC Keck School of Medicine)

Project period: 12/31/2007-11/31/2012

Total Amount of Award: $ 3,435,109 (USC School of Engineering Share: $458,052)

 

  1. Cardiopulmonary Health Effects: Toxicity of Semi-volatile and Non volatile Components of Ultrafine PM.

 

Funding Source: California Air Resources Board (CARB)

Role:  Co-Principal Investigator (with Dr. Michael Kleinman, UC Irvine)

Project period: 02/01/2009- 12/31/2012

Total Amount of Award: $ 520,641 (USC’s share)

 

  1. In-Vehicle Air Pollution Exposure Measurement and Modeling for Pregnant Women in the National Children’s Study

Funding Source: California Air Resources Board (CARB)

Role:  Co-Principal Investigator (with Dr. Ralph Delfino, UC Irvine)

Project period: 02/01/2008-12/31/2012

Total Amount of Award: $ 503,890 (USC’s share)

 

  1. Source Apportionment of Carbonaceous Aerosols Using Integrated Multi-Variant and Source Tracer Techniques and a Unique Molecular Marker Data Set

Funding Source: California Air Resources Board (CARB)

Role:  Co-Principal Investigator (with Dr. James Schauer, University of Wisconsin – Madison)

Project period: 02/01/2008-12/31/2011

Total Amount of Award: $ 163,670 (USC’s share)

 

  1. “Development of a Versatile Aerosol Concentration System ( VACES ) for Inhalation Exposure Studies”

Funding Source: University of Texas

Role:  Principal Investigator

Project period: 04/01/2012- 02/01/2013

Total Amount of Award: $ 85,000

 

  1. “Development of a Versatile Aerosol Concentration System ( VACES ) for Inhalation Exposure Studies”

Funding Source: Max Planck Institute

Role:  Principal Investigator

Project period: 04/01/201o- 02/01/2011

Total Amount of Award: $ 75,000

 

  1. Health effects of PM particles emitted from heavy-duty vehicles-A comparison between different fuel formulations

Funding Source: South Coast Air Quality Management District-AQMD

Role:  Co-Principal Investigator (PI: Dr. George Karavalakis, UC Riverside))

Project period: 04/01/2012- 09/01/2013

Total Amount of Award: $ 55,000 (C. Sioutas share only)

 

  1. Sources, Composition, Variability and Toxicological Characteristics of Ultrafine Particles in Southern California

Funding Source: South Coast Air Quality Management District (SCAQMD)

Role:  Principal Investigator Project period: 01/01/2011-12/01/2015

Total Amount of Award: $ 498,900

 

  1. Air Pollution and Vulnerability to Alzheimer-like Neuro-degeneration in Transgenic Models

Funding Source: NIH

Role:  Co-Principal Investigator (PI: Dr. Caleb Finch, USC Dept of Gerontology)

Project period: 10/01/2011- 12/01/2015

Total Amount of Award: $ 160,000 (C. Sioutas share only)

 

  1. Development of a Versatile Aerosol Concentration System to study optical aerosol properties

Funding Source: University of Vienna

Role:  Principal Investigator

Project period: 04/01/2013- 02/01/2015

Total Amount of Award: $ 85,000

 

  1. Development of a Versatile Aerosol Concentration System ( VACES ) for Inhalation Exposure Studies

Funding Source: University of Bern, Switzerland

Role:  Principal Investigator

Project period: 11/01/2013- 12/01/2014

Total Amount of Award: $ 75,000

 

  1. Source Apportionment of PM2.5 in the 8 STN/chemical speciation sites of the state of California

Funding Source: Office of Environmental Health Hazard Assessment (OEHHA)

Role: Principal Investigator

Project period: 07/01/2013- 12/01/2016

Total Amount of Award: $ 254,000

 

  1. Peripheral Blood Gene Expression in Subjects with Coronary Artery Disease and Exposure to Particulate Air Pollutant Components and Size Fractions

Funding Source: California Air Resources Board (CARB)

Role:  Co-Principal Investigator (with Dr. Ralph Delfino, UC Irvine)

Project period: 08/01/2010-08/31/2016

Total Amount of Award: $ 298,900 (USC’s share at USC: $114,822)

 

  1. Evaluation of Ambient Particulate Matter Neurotoxicity Using Primary Human Brain Cells

Funding Source: South Coast Air Quality Management District

Role: Co-Principal Investigator  (PI: Dr. Arezoo Campbell, Western University)

Project period: 08 /01/2013- 12/01/2016

Total Amount of Award: $ 575,000 (C. Sioutas share at USC; $195,500)

 

  1. Genetic and Epigenetic Programming of Allergic Airway Inflammation

Funding Source: NIH/NIAID

Role:  Co-Principal Investigator (PI: Dr. Talal Chatila, Harvard Medical School)

Project period: 04/01/2012- 04/01/2017

Total Amount of Award: $ 486,233 (C. Sioutas share at USC)

 

  1. Transcriptomics, Oxidative Stress, and Inflammatory Responses to Air Pollutants in an Elderly Cohort

Funding Source: NIEHS/NIH

Role:  Co-Principal Investigator (PI: Dr. Ralph Delfino, UC Irvine)

Project period: 06/01/2011- 06/01/2017

Total Amount of Award: $ 2,500,000 (C. Sioutas share at USC: $787,867

 

  1. The relation of cardiovascular health outcomes to the oxidative potential of particulate air pollution

Funding Source: South Coast Air Quality Management District

Role:  Co- Principal Investigator  (PI- Ralph Delfino, UC Irvine)

Project period: 10/01/2013- 12/01/2017

Total Amount of Award: $ 345,000 (C. Sioutas share at USC; $112,000)

 

  1. Measurement of Outdoor Ambient Ultrafine Particulates for a Study of Lung Cancer Risk in California

Funding Source: National Cancer Institute

Role: Principal Investigator

Project period: 07/01/2015 – 09/01/2017

Total Amount of Award: $ 300,000

 

  1. Development of fine airborne particulate matter (PM) concentrator

Funding Source:  University of Maryland

Role: Principal Investigator

Project period: 10 /01/2017 – 09/01/2018

Total Amount of Award: $ 96,000

 

  1. Southern California Children’s Environmental Health Center (SC-CEHC), Project 3

Funding Source  NIEHS/EPA, P01 ES022845 (R McConnell, PI; C Sioutas, Co-I)

Performance Period: 07/01/2013 – 05/31/2018

Total Amount of Award: $ 79,052 (USC C. Sioutas share only))

 

  1. Development of an ambient particulate matter (PM) concentrator

Funding Source:  Fudan University

Role: Principal Investigator

Project period: 01/01/2018 – 09/01/2019

Total Amount of Award: $ 113,000